Yes, Vilitra 10mg, which contains the active ingredient vardenafil, can increase the risk of priapism in men with sickle cell disease (SCD). Priapism is a prolonged and painful erection that can cause tissue damage if not treated promptly. In individuals with SCD, the blood flow is already compromised due to sickle-shaped red blood cells, which increases the likelihood of developing priapism. The use of medications like vardenafil, which enhance blood flow to the penis, may exacerbate this risk in men with SCD, potentially leading to a medical emergency. Therefore, it's crucial for men with SCD to consult a healthcare provider before using medications like Vilitra.